Senate
- Agriculture: Chair Senator Blanche Lincoln (D-AR) lost
- Banking: Chair Chris Dodd (D-CT) didn’t run again, Senator Robert Bennett (R UT) lost the nomination
- Energy and Natural Resources: Ranking member Senator Lisa Murkowski (R AK) appears to win her write-in campaign
- Finance: Senator Blanche Lincoln (D-AR) lost
- Judiciary: Senator Russ Feingold (D-WI) lost
- Agriculture: 13 of 28 Democrats lost, 2 Democrats did not run
- Appropriations: 6 of 37 Democrats lost, 4 Democrats died or did not run again
- Armed Services: Chair Ike Skelton (D-MO 4) lost along with 8 other of 37 Democrats, 5 Democrats did not run again
- Budget: Chair John Spratt (D-SC 5) lost along with 3 other of the 24 Democrats, 2 Democrats did not run again
- Energy and Commerce: 3 of 36 Democrats lost, 2 Democrats did not run
- Financial Services: 11 of 42 Democrats lost, 2 Democrats did not run
- Science and Technology: 7 of 27 Democrats lost, 2 Democrats including Chair Bart Gordon (D-TN 6) did not run again
- Transportation and Infrastructure: Chair James Oberstar (D-MN 8) lost along with 14 other Democrats of 45, 1 Democrat did not run again
- Veterans Affairs: 11 of 18 Democrats lost, 1 Democrat did not run again
- Ways and Means: 2 of 26 Democrats lost, 2 Democrats did not run